Resources

 

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Our papers

Hartley S, Stelmach A, Delborne JA, Barnhill-Dilling SK 2023 Moving beyond narrow definitions of gene drive: Diverse perspectives and frames enable substantive dialogue among science and humanities teachers in the US and UK Public Understanding of Science

Hartley S, Kokotovich A, Devos Y and Mumford J 2023 Engagement on risk assessment for gene drive mosquitoes by EFSA and Target Malaria Environmental Science and Policy

Connolly JB, Mumford JD, Glandorf B, Hartley S, Lewis OT, Turner G, Beech C, Sykes N, Coulibaly M, Romeis J, Teem J, Tonui W, Evans SW, Lovett B, Mankad A, Mnzava A, Fuchs S, Hackett T, Landis W, Marshall J, Aboagye Antwi F 2022 Recommendations for environmental risk assessment of gene drive applications for malaria vector control Malaria Journal 21: 152

Hartley S, Taitingfong R and Fidelman P 2022 The principles driving gene drives for conservation Environmental Science and Policy 135: 36-45

Ledingham K, Opesen C and Hartley S (R&R) The role of social scientists in gene drive research in Uganda and Mali Journal of Responsible Innovation

Backus GA & Delborne JA 2019 Threshold-dependent gene drives in the wild: spread, controllability and ecological uncertainty BioScience 69(11) 900–907

Barnhill‐Dilling SK & Delborne JA 2021 Whose intentions? What consequences? Interrogating 'intended consequences' for conservation with environmental biotechnology Conservation Science and Practice 3(4) e406

De Campos A, Hartley S, de Koning C, Lezaun J & Velho L 2017 Responsible Innovation and political accountability: genetically modified mosquitoes in Brazil Journal of Responsible Innovation, 4(1), 5–23

De Graeff N, Jongsma KR, Johnston J, Hartley S & Bredenoord AL 2019 The ethics of genome editing in non-human animals: A systematic review of reasons reported in the academic literature Philosophical Transactions of the Royal Society B: Biological Sciences, 374(1772). Download PDF: De Graeff et al (2019) The ethics of genome editing in non-human animals

Delborne JA, Binde AR, Rivers, L, Cavin Barnes J, Barnhill-Dilling K, George D … Sudweeks J 2018 Biotechnology, the American chestnut tree, and public engagement: Workshop report

Delborne JA, Kokotovich AE & Lunshof JE 2020 Social license and synthetic biology: the trouble with mining terms Journal of Responsible Innovation 7(3) 280–297

Delborne JA, Kuzma J, Gould F, Frow E, Leitschuh C & Sudweeks J (Eds) 2018 Special Issue: Roadmap to gene drives: research and governance needs in social, political and ecological context: vol. 5 (sup1) Routledge/Taylor and Francis.

Farooque M, Barnhill-Dilling SK, Shapiro J & Delborne J 2019 Exploring stakeholder perspectives on the development of a gene drive mouse for biodiversity protection on islands [Workshop Report] Genetic Engineering and Society Center.

George DR, Kuiken T & Delborne JA 2019 Articulating “free, prior and informed consent” (FPIC) for engineered gene drives Proceedings of the Royal Society B: Biological Sciences, 286(20191484)

Godwin J, Serr M, Barnhill-Dilling SK, Blondel DV, Brown PR, Campbell K, Delborne J, Lloyd AL, Oh KP, Prowse TAA, Saah R & Thomas P 2019 Rodent gene drives for conservation: opportunities and data needs Proceedings of the Royal Society B: Biological Sciences 286(1917) 20191606

Hartley S & Kokotovich A 2018 Disentangling risk assessment: new roles for experts and publics. In B. Nerlich, S. Hartley, S. Raman & A. Smith (Eds), Science and the Politics of Openness: Here be monsters (pp. 176–194). Manchester: Manchester University Press

Hartley, Sarah 2016 Policy masquerading as science: an examination of non-state actor involvement in European risk assessment policy for genetically modified animals Journal of European Public Policy, 23(2), 276–295 

Hartley S, Thizy D, Ledingham K, Coulibaly M, Diabaté A, Dicko B, … Toé LP 2019 Knowledge engagement in gene drive research for malaria control PLoS Neglected Tropical Diseases, 13(4), 1–5 Download PDF: Hartley et al 2019 Knowledge engagement in gene drive research for malaria control

Hartley S, Ledingham K, Owen R, Leonelli S, Diarra S & Diop S (2021) Experimenting with co-development: a qualitative study of gene drive research for malaria control in Mali Social Science and Medicine, 276(113850) Download PDF: Hartley et al 2021 Experimenting with co-development. A qualitative study of gene drive research for malaria control in Mali

Hartley S, Kokotovich A, Opesen C, Habtewold T, Ledingham K, Raymond B & Rwabukwali C 2021 Ugandan stakeholder hopes and concerns about gene drive mosquitoes for malaria control: new directions for gene drive risk governance Malaria Journal, 20(149), 1–13 Download PDF: Hartley et al 2021 Ugandan stakeholder hopes and concerns about gene drive mosquitoes for malaria control. new directions for gene drive risk governance

Hartley S, Kokotovich A and McCalman C 2022 Engagement in risk assessment: Prescription and practice in the international development of gene drive risk assessment guidelines (2014-2020) Regulation and Governance

Jones MS, Delborne JA, Elsensohn J, Mitchell PD & Brown ZS 2019 Does the U.S. public support using gene drives in agriculture? And what do they want to know? Science Advances 5(9) eaau8462

Kofler N and Taitingfong R 2020 Advances in genetic engineering test democracy's capacity for good decision-making The Boston Globe.  

Kokotovich AE, Delborne JA, Elsensohn J & Burrack H 2020 Emerging technologies for invasive insects: the role of engagement Annals of the Entomological Society of America 113(4) 266–279

Ledingham K & Hartley S 2020 Transformation and slippage in co-production ambitions for global technology development: The case of gene drive Environmental Science and Policy, 116 (October 2020), 78–85 Download PDF: Ledingham K and Hartley S 2020 Transformation and slippage in co-production ambitions for global technology development. The case of gene drive

Long KC, Alphey L, Annas GJ, Bloss CS, Campbell KJ, Champer J … Akbari OS 2021 Core commitments for field trials of gene drive organisms Science, 370(6523), 1417–1419 Download PDF: Long KC, Alphey L, Annas GJ, Bloss CS, Campbell KJ, Champer J ... & Akbari OS 2020 Core commitments for field trials of gene drive organisms

Nerlich B and Stelmach A 2022 Gene drive communication: Exploring experts’ lived experience of metaphor use. New Genetics and Society

Russell A W, Stelmach A, Hartley S, Carter L, & Raman S (2022) Opening up, closing down, or leaving ajar? How applications are used in engaging with publics about gene drive. Journal of Responsible Innovation, 1-22

Schairer CE, Taitingfong R, Akbari OS, Bloss CS 2019 A typology of community and stakeholder engagement based on documented examples in the field of novel vector control PLOS Neglected Tropical Diseases 13(11): e0007863

Stelmach A, Nerlich B and Hartley S 2022 Gene drives in the UK, US and Australian press, (2015-2019): How a new focus on responsibility is shaping science communication. Science Communication

Stirling A, Hayes KR & Delborne J 2018 Towards inclusive social appraisal: risk, participation and democracy in governance of synthetic biology BMC Proceedings 12(8) 15

Taitingfong R 2020 Islands as laboratories: indigenous knowledge and gene drives in the Pacific Human Biology 91(3):179-188

Taitingfong R L, Triplett C, Vásquez V N, Rajagopalan R, Raban R, Roberts A, … Smith R, ... & Bloss, C. S. (2022). Exploring the value of a global gene drive project registry. Nature Biotechnology

Thizy D, Emerson C, Gibbs J, Hartley S, Kapiriri L, Lavery J, … Robinson B 2019 Guidance on stakeholder engagement practices to inform the development of area-wide vector control methods PLoS Neglected Tropical Diseases, 13(4), 1–11 Download PDF: Thizy et al 2019 Guidance on stakeholder engagement practices to inform the development of area-wide vector control methods

Thizy D, Pare Toe L, Mbogo C, Matoke-Muhia D, Alibu VP, Barnhill-Dilling SK … Tountas KH 2021 Proceedings of an expert workshop on community agreement for gene drive research in Africa - co-organised by KEMRI, PAMCA and Target Malaria Gates Open Research 5, 1–15

Zhou L, Alphey N, Walker AS, Travers L, Morrison NI, Bonsall MB, Raymond B 2018 The application of self-limiting transgenic insects in managing resistance in experimental metapopulations Journal of Applied Ecology doi: 10.1111/1365-2664.13298

Related resources 

AAS (Australian Academy of Sciences) 2017 Synthetic gene drives in Australia: implications of emerging technologies Canberra

Adelman Z, Akbari O, Bauer J, Bier E, Bloss C, Carter SR … Wozniak C 2017 Rules of the road for insect gene drive research and testing Nature Biotechnology 35(8) 716–718

Akbari BOS, Bellen HJ, Bier E, Bullock SL, Burt A, Church GM … Knoblich J 2015 Safeguarding gene drive experiments in the laboratory Science 349 (6251) 927–929

AUDA-NEPAD 2018 Gene Drives for Malaria Control and Elimination in Africa

AUDA-NEPAD 2020 Position Paper: Strengthening AU Member States’ regulatory capacities for responsible research towards elimination of malaria in Africa Johannesburg: African Union Development Agency

Alphey L S, Crisanti A, Randazzo F & Akbari OS 2020 Standardizing the definition of gene drive PNAS, 117(49), 30864-30867  

Annas et al 2021 A code of ethics for gene drive research CRISPR Journal 4, 19-21

Beisel U & Ganle J 2019 The release of genetically engineered mosquitoes in Burkina Faso: bioeconomy of science, public engagement and trust in medicine African Studies Review 6(3), 62164–62173

Christophe Boëte 2018 Gene drive and trust in science: Lobbying and propaganda around gene drive technologies threaten to erode public trust in science. Genewatch : a bulletin of the Committee for Responsible Genetics, 2018, 31 (1). ffhal-01944467f

Brossard D, Belluck P, Gould F & Wirz CD 2019 Promises and perils of gene drives: Navigating the communication of complex, post-normal science PNAS, 116(16), 7692-7697

Burall S 2018 Rethink public engagement for gene editing Nature 438–439

Burgess MM, Mumford JD & Lavery JV 2018 Public engagement pathways for emerging GM insect technologies BMC Proceedings 12, 12

Callaway E 2018 UN treaty agrees to limit gene drives but rejects a moratorium Nature, November 29

Callaway E 2018 Controversial CRISPR ‘gene drives’ tested in mammals for the first time Nature 559(7713) 164 

Caplan AL, Parent B, Shen M & Plunkett C 2015 No time to waste - the ethical challenges created by CRISPR EMBO Reports 16(11), 1421–1426

Carroll D, Van Eenennaam AL, Taylor JF, Seger J & Voytas DF 2016 Regulate genome-edited products, not genome editing itself Nature Biotechnology34(5) 477–4 79

Carter SR & Friedman RM 2016 Policy and regulatory issues for gene drives in insects Workshop Report La Jolla, California 

Charo RA & Greely HT 2015 CRISPR critters and CRISPR cracks American Journal of Bioethics 51(12) 11–17

Cheung C, Gamez S, Carballar-Lejarazú R, Ferman V, Vásquez VN, Terradas G, Ishikawa J, Schairer CE, Bier E, Marshall JM, James AA, Akbari OS & Bloss CS 2020 Translating gene drive science to promote linguistic diversity in community and stakeholder engagement Global Public Health 15(10) 1551-1565

Chu KM, Jayaraman S, Kyamanywa P & Ntakiyiruta G 2014 Building research capacity in Africa: equity and global health collaborations PLoS Medicine 11(3) 1-4

Courtier-Orgogozo V, Morizot B and Boëte C 2017 Agricultural pest control with CRISPR-based gene drive: time for public debate EMBO rep 18, 878-880

De Graeff et al 2021 Governing Gene Drive Technologies: A Qualitative Interview Study AJOB Empirical Bioethics

Devos Y, Craig W, Devlin RH, Ippolito A, Leggatt RA, Romeis J, Shaw R, Svendsen C and Topping CJ 2019 Using problem formulation for fit-for-purpose pre-market environmental risk assessments of regulated stressors EFSA Journal 17(S1):e170708, 31

Edwards O, Brown P, Tizard M, Strive T & Sheppard A 7th December 2017 Taking a responsible approach to new genetics technologies for conservation ECOS

EFSA Panel on Genetically Modified Organisms (GMO) Naegeli H, Bresson JL, Dalmay T, Dewhurst IC, Epstein MM … Firbank LG 2020 Adequacy and sufficiency evaluation of existing EFSA guidelines for the molecular characterisation, environmental risk assessment and post-market environmental monitoring of genetically modified insects containing engineered gene drives EFSA Journal 18(11)

Emerson C, James S, Littler K & Randazzo F 2017 Principles for gene drive research Science 358(6367) 1135–1136

Esvelt K 2016 Gene editing can drive science to openness Nature 534, 153

Esvelt KM & Gemmell NJ 2017 Conservation demands safe gene drive PLoS Biology 15(11) 1-8

Esvelt K 2018 Gene drive technology: The thing to fear is fear itself George Mason University: Mason Archival Repository Service

Famakinde DO 2020 Public health concerns over gene-drive mosquitoes: will future use of gene-drive snails for schistosomiasis control gain increased level of community acceptance? Pathogens and Global Health 114(2) 55-63

Finda MF, Christofides N, Lezaun J, Tarimo B, Chaki P, Kelly AH … Okumu FO 2020 Opinions of key stakeholders on alternative interventions for malaria control and elimination in Tanzania Malaria Journal 19(1) 1–13

GeneConvene Virtual Institute https://www.geneconvenevi.org/

Glover B, Akinbo O, Savadogo M, Timpo S, Lemgo G, Sinebo W, … Ambali A 2018 Strengthening regulatory capacity for gene drives in Africa: Leveraging NEPAD’s experience in establishing regulatory systems for medicines and GM crops in Africa BMC Proceedings 12(Suppl 8)

James S, Collins FH, Welkhoff PA, Emerson C, Godfray HCJ, Gottlieb M, Greenwood B, Lindsay SW, Mbogo CM, Okumu FO, Quemada H, Savadogo M, Singh JA, Tountas KH & Touré YT 2018 Pathway to Deployment of Gene Drive Mosquitoes as a Potential Biocontrol Tool for Elimination of Malaria in Sub-Saharan Africa: Recommendations of a Scientific Working Group The American Journal of Tropical Medicine and Hygiene 98(6_Suppl) 1-49

James S & Tountas KH 2018 Using gene drive technologies to control vector-borne infectious diseases Sustainability 10(12) 1-7

Jamrozik E, De La Fuente-Núñez V, Reis A, Ringwald P & Selgelid MJ 2015 Ethical aspects of malaria control and research Malaria Journal 14(1) 1-7 

Kamenova K, Akerman J & Emerson C 4 November 2017 Into the Unknown: Framing Uncertainty and Risk in News Media Portrayal of Gene Drive Technology [Conference paper] Communications Workshop At: Baltimore, MD, USA

Kayondo JK 2018 Africa must not wait for advances in malaria innovation – we must pioneer them Retrieved 27 January 2020 from telegraph.co.uk website

Kelsey A, Stillinger D, Pham TB, Murphy J, Firth S & Carballar-Lejarazú R 2020 Global Governing Bodies: A Pathway for Gene Drive Governance for Vector Mosquito Control The American journal of tropical medicine and hygiene 103(3) 976-985

Kofler N, Collins JP, Kuzma J, Marris E, Esvelt K, Nelson MP … Schmitz OJ 2018 Editing nature: Local roots of global governance Science 362(6414) 527–529

Kolopack PA & Lavery JV 2017 Informed consent in field trials of gene-drive mosquitoes Gates Open Research 1 May 1–12

Kuzma J 2019 Procedurally robust risk assessment framework for novel genetically engineered organisms and gene drives Regulation and Governance

Kuzma J & Rawls L 2016 Engineering the wild: gene drives and intergenerational equity Jurimetrics, 56(3) 279–296

Kuntz M 2016 Scientists should oppose the drive of postmodern ideology Trends in Biotechnology 34 (12) 943– 945

MacDonald EA, Edwards ED, Balanovic J, Medvecky F 2021 Scientifically framed gene drive communication perceived as credible but riskier People and Nature 3, 457-468.

MacDonald EA, Balanovic J, Edwards ED, Abrahamse W et al 2020 Public opinion towards gene drive as a pest control approach for biodiversity conservation and the association of underlying worldviews Environmental Communication 14(7) 904-918

Marshall JM 2010 The Cartagena Protocol and genetically modified mosquitoes Nature Biotechnology 28(9) 1–2

Mshinda H, Killeen G, Mukabana W, Mathenge E, Mboera L & Knols B 2004 Development of genetically modified mosquitoes in Africa Lancet Infectious Diseases 4, 264–265

Nakkazi E 2020 Fighting malaria with genetically modified mosquitoes The BMJ 370

NASEM 2016 Gene drives on the horizon: advancing science, navigating uncertainty, and aligning research with public values Washington DC: National Academies of Sciences Engineering and Medicine. Retrieved from National Academies of Sciences Engineering and Medicine website

Nchabi Kamwi R 2016 Gene drive debate must include voices from Africa, elsewhere Retrieved 27 January 2020 from statnews.com website

Neuhaus CP & Caplan AL 2017 Ethical lessons from a tale of two genetically modified insects Nature Biotechnology 35(8) 713–716

Neuhaus, Carolyn P 2018 Community engagement and field trials of genetically modified insects and animals Hastings Center Report 48(1) 25–36

Neuhaus, Carolyn P & Caplan AL 2017 Genome editing: Bioethics shows the way PLoS Biology 15(3) 1-5

Neves MP & Druml C 2017 Ethical implications of fighting malaria with CRISPR/Cas9 BMJ Global Health, 2(3) 9–11 

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Sankar PL & Cho MK 2015 Engineering values Into genetic engineering: A proposed analytic framework for scientific social responsibility The American Journal of Bioethics 15:12, 18-24   

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Schairer CE, Triplett C, Buchman A, Akbari OS & Bloss CS 2020 Interdisciplinary development of a standardized introduction to gene drives for lay audiences BMC Medical Research Methodology 20, 273

Schultz-Bergin M 2014 Making better sense of animal disenhancement: a reply to Henschke NanoEthics, 8(1) 101–109

Scudellari M 2019 Self-destructing mosquitoes and sterilized rodents: the promise of gene drives Nature 571, 160–162

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